After discussion with the family, a decision was made to take her emergently to the cardiac catheterization laboratory. Disclosures: Consultant to Penumbra, Inc. An 83-year-old woman transferred from an outside hospital presented with acute shortness of breath, was hypotensive, and was intubated. As part of the INDIGO Aspiration System, the INDIGO Sterile Aspiration Tubing is indicated to connect the INDIGO Aspiration Catheters to the Penumbra Aspiration Pump. 2. A final angiogram revealed complete reperfusion to the dominant left circumflex artery and branches, with TIMI 3 flow (Figure 3). K180412. CAT8XTORQ115KIT-NS. Do not use in oxygen rich environment. Tareq Kass-Hout. Excessive aspiration or failure to close the INDIGO Aspiration Tubing valve when aspiration is complete is not recommended. The system uses Penumbra's RED reperfusion catheters. Available in a selection of sizes, the CAT family can enable access to distal peripheral vessels of the upper and lower extremities, including below the knee. . Do not use automated high-pressure contrast injection equipment with the INDIGO Aspiration Catheter because it may damage the device. Prior to use, please consult device labeling and instructions for use. Additional Details. 0, 23. allergic reaction and anaphylaxis from contrast media; acute occlusion; air embolism; arteriovenous fistula; death; device malfunction; distal embolization; emboli; false aneurysm formation; hematoma or hemorrhage at access site; inability to completely remove thrombus; infection; hemorrhage; ischemia; kidney damage from contrast media; neurological deficits including stroke; vessel spasm, thrombosis, dissection, or perforation; intimal disruption; myocardial infarction; emergent surgery; fibrillation; hypotension; respiratory failure; peripheral thromboembolic events. Initial angiography revealed an occlusion of the distal RCA. CAT7 and CAT12 are the next generation of the Indigo System catheters. Excessive aspiration or failure to close the INDIGO Aspiration Tubing when aspiration is complete is not recommended. Use of this equipment adjacent to or stacked with other equipment should be avoided because it could result in improper operation. Figure 2. The product-specific content of this website is intended for use by healthcare professionals only. The Indigo System CAT3, CAT5, CAT6, CAT8, CATD, and CAT7D are engineered to be robust, trackable, atraumatic, and well suited for the peripheral anatomy. Smidt Heart institute The built-in microprocessor features a proprietary thrombus removal algorithm that automatically controls a valve in the tubing to provide continuous or intermittent aspiration. The Indigo Separator 4 is not intended for use as a guidewire. The Swan-Ganz catheter was exchanged over a long V18 wire. Do not use kinked or damaged devices. Lightning comes packaged with the Indigo CAT7, CAT8 or CAT12. If the cause cannot be determined, withdraw the device or system as a unit. Prior to use, please consult device labeling and instructions for use. Return all damaged devices and packaging to the manufacturer/distributor. Vedantham S, Goldhaber SZ, Julian JA, et al. Common emitters (such as RFID emitters, security systems, diathermy equipment, and portable transmitters) should not be used in close proximity to the Penumbra ENGINE as they can interfere with and result in degradation of the performance of the equipment. When performing aspiration, ensure that the INDIGO Aspiration Tubing is open for only the minimum time needed to remove thrombus. The Indigo System CAT RX was the preferred choice for mechanical aspiration thrombectomy to remove the distal emboli below the knee in the posterior tibial artery. The complaint indicated that the cat8 was kinked during the procedure. allergic reaction and anaphylaxis from contrast media; acute occlusion; air embolism; arteriovenous fistula; death; device malfunction; distal embolization; emboli; false aneurysm formation; hematoma or hemorrhage at access site; inability to completely remove thrombus; infection; hemorrhage; ischemia; kidney damage from contrast media; neurological deficits including stroke; vessel spasm, thrombosis, dissection, or perforation; intimal disruption; myocardial infarction; emergent surgery; fibrillation; hypotension; respiratory failure; peripheral thromboembolic events. Indigo Separator 4 is intended to be used with Indigo CAT RX Aspiration Catheter to clear the distal end of the catheter lumen should it be blocked with thrombus. With automatic valve control, Lightning can help the physician focus on optimizing thrombus removal procedures. Indigo Aspiration System Intended Use Portable RF communications equipment (including peripherals such as antenna cables and external antennas) should be used no closer than 30 cm (12 inches) to any part of the Penumbra ENGINE. Also find Catheter price list from verified suppliers with contact number | ID: 23694008673 Peripheral Thrombectomy Indigo System Mechanical Thrombectomy CAT6 Indigo Catheter 6, Straight tip 135cm. Penumbra, Inc. One Penumbra Place. Since launch, we have found that CAT RX has become an essential part of our treatment algorithm when thrombus is present in the coronaries. The Indigo System CAT RX and Penumbra ENGINE aspiration source were crucial to the success of this case. Its engineers designed low-profile, high-power aspiration catheters called Cat 7 and Cat 12 that were launched in 2021. Indigo Aspiration Catheters (CAT) are the foundation of Penumbra's Indigo System.The Indigo System CAT3, CAT5, CAT6, CAT8 and CATD are engineered to be robust, durable, and trackable for use in the peripheral anatomy. Missouri Baptist Medical Center Use the INDIGO Aspiration System in conjunction with fluoroscopic visualization. N Engl J Med. Foi utilizado o dispositivo Penumbra Indigo System Separator SEP8 (Penumbra Inc.), via . There was an immediate response in the clinical situation of the patient: her blood pressure stabilized into the 90s and her oxygenation improved substantially. The low-profile catheter and Penumbra ENGINE are easy to set up and use. Prior to use, please refer to the Instructions for Use for complete product indications, contraindications, warnings, precautions, potential adverse events, and detailed instructions for use. Penumbra Aspiration Pump: The Penumbra Aspiration Pump is indicated as a vacuum source for Penumbra Aspiration Systems. The Indigo System CAT3, CAT5, CAT6, CAT8 and CATD ?are engineered to be robust, durable, and trackable for use in the peripheral anatomy. 510 (k) Number. Learn more about Lightning. Do not reuse. The Penumbra Aspiration Pump is indicated as a vacuum source for Penumbra Aspiration Systems. These benefits may suggest a reduction to cost of care, improved patient outcomes, and changes to the procedural algorithm. Director of Cardiac Catheterization Lab, PERT & Structural Heart At our institutions, we are using CAT RX for patients who present with fresh soft thrombi or emboli. This allowed prompt treatment of patients with minimal intensive care unit days and early discharge from the hospital. 5 and 94. The Indigo System utilises the Penumbra ENGINE aspiration source capable of delivering nearly pure, continuous vacuum (-29 inHg or 98.2 kPa) to our catheters, enabling thrombus removal in vessels of various sizes. As part of the Indigo Aspiration System, the Indigo CAT RX Aspiration Catheters and Indigo Separator 4 are indicated for the removal of fresh, soft emboli and thrombi from vessels in the coronary and peripheral vasculature. Continuous Aspiration Mechanical Thrombectomy Catheters (CAT) are the foundation of Penumbra's Indigo System. A second angiogram showed extensive clot burden spread across multiple branches (Figure 2). Indigo System CAT RX has been designed to address the limitations of traditional treatment options with manual aspiration. Ultrasound-guided access was obtained through the right femoral vein. The Indigo Aspiration System is intended for the removal of fresh, soft emboli and thrombi from vessels of the peripheral arterial and venous systems and certain central circulatory system conditions such as pulmonary emboli using continuous aspiration. Unit may overheat and shut off or fail to restart if run for extended periods of time without airflow. In patients with submassive pulmonary embolism with compromised right ventricular function and elevated biomarkers, the Indigo System is an excellent frontline tool offering a safe and effective1 treatment option. Caution: Federal (USA) law restricts this device to sale by or on the order of a physician. Sista A. Indigo aspiration system for acute pulmonary embolism. This content is not intended to offer professional medical advice. The initial angiogram revealed TIMI 0 flow in the proximal right coronary artery (RCA) due to plaque rupture. The patient underwent six shocks and was intubated while CAT RX was delivered through the freshly placed 3.5- X 38-mm DES to the PDA. The procedure can be performed quickly,1 which is important for symptomatic patients. The Penumbra Aspiration Pump is indicated as a vacuum source for Penumbra Aspiration Systems. The canister is intended for single use only. All Rights Reserved Privacy Policy, With S. Jay Mathews, MD, MS, FACC; Chris Metzger, MD; Waqas R. Qureshi, MD, MS; Jawairia Sahar K. Mirza, MBBS; Gus Theodos, MD, FACC, FSCAI; Brian Kolski, MD; Suhail Dohad, MD, FACC. Figure 2. Return all damaged devices and packaging to the manufacturer/distributor. 0, 26. Precautions UPC: Current Stock: . These were quickly followed by the release of the 8-F CAT8 and 6-F CAT6 in 2015. Do not use in the presence of a flammable anesthetic mixture with air or nitrous oxide. These types of burns heal withing 5 or 6 days without permanent scarring. If such use is necessary, LIGHTNING Aspiration Tubing and the other equipment should be observed to verify that they are functioning properly. The patient had a robust recovery and was discharged to her rehab facility on anticoagulation. Mechanical Thrombectomy. The patient vomited the ticagrelor within 2 hours of administration and cangrelor was started. Copyright 2022 Penumbra, Inc. All rights reserved. Warnings Do not use the INDIGO Aspiration System with a pump other than a Penumbra Aspiration Pump. Disclosures: Consultant to Penumbra, Inc. A 92-year-old man with a history of coronary artery disease (treated previously with coronary artery bypass graft) and severe aortic stenosis (treated previously with transcatheter aortic valve replacement) presented to the ED with chest pain. The patient was brought to the catheterization laboratory for angiography that showed stagnant flow through the saphenous vein graft (SVG; Figure 1). This website is intended for US audience only. The product-specific content of this website is intended for use by healthcare professionals only. Latest System Designed for Single Session Arterial Thrombus Removal News Ruby Coil, POD, and Packing Coil are large-volume coils designed for embolization of the peripheral arterial and venous systems. Maintain a constant infusion of appropriate flush solution. The CAT family of catheters is the foundation of Penumbras Indigo System. Maintain a constant infusion of appropriate flush solution. Mechanical power aspiration with a continuous vacuum source and large lumen aspiration catheter was first introduced in the neurovascular space when Penumbra revolutionized thrombus removal for acute ischemic stroke patients. Use only waterbased solvents for cleaning. In a retrospective analysis of patients in our practice with fresh thrombus burden, we have observed TIMI 3 restored when using CAT RX frontline.1 This is another positive patient outcome with the use of CAT RX in a case of high thrombus burden. The Indigo System CAT3, CAT5, CAT6, CAT8 and CATD ?are engineered to be robust, durable, and trackable for use in the peripheral anatomy. chronic clot, atherosclerotic plaque) The cerebral vasculature Warnings The INDIGO Aspiration System should only be used by physicians who have received appropriate training in interventional techniques. The CAT family of catheters is the foundation of Penumbra's Indigo system. minimalism: a documentary about the important things transcript; cat8 penumbra catheter; i 75 road construction cincinnati; tocaya west hollywood; best places to live in alabama near the. The Indigo CAT RX Aspiration Catheters and Indigo Separator 4: With S. Jay Mathews, MD, MS, FACC; Chris Metzger, MD; Waqas R. Qureshi, MD, MS; Jawairia Sahar K. Mirza, MBBS; Gus Theodos, MD, FACC, FSCAI; Brian Kolski, MD; and Suhail Dohad, MD, FACC. Penumbra introduced the Indigo System CAT RX in 2017 for the removal of fresh, soft emboli and thrombi from the . Otherwise, this could result in degradation of the performance of this equipment. Penumbras IndigoAspiration System can be used to remove emboli and thrombi from vessels of the peripheral arterial and venous systems, and for treatment of pulmonary embolism. Remove and service the Penumbra ENGINE if liquids or solids have been drawn into the Penumbra ENGINE. The Penumbra CAT RX catheter was used in a total of 34 patients, with 71% STEMI, 23% NSTEMI, 3% UA, and 3% new onset heart failure. The combination of computer-aided aspiration and large-lumen catheter engineering form Lightning 7 and Lightning 12: the latest generation in clot removal technology. Copyright 2022 Penumbra, Inc. All rights reserved. Randomized trial of primary PCI with or without routine manual thrombectomy. A Penumbra CAT8 catheter was placed into the right upper lobe, right middle lobe, and right lower lobe, and aspiration with a separator was performed. Do not use open or damaged packages. Within 72 hours, repeat echocardiography showed RV/LV ratio improvement from 1.43 to 0.98. Available in a selection of sizes, the CAT family can provide access to distal peripheral vessels of the upper and lower extremities, including below the knee. With automatic valve control, Lightning can help the physician focus on optimising thrombus removal procedures. Initial experience with a mechanical aspiration catheter for thrombus removal during percutaneous intervention: a multicenter retrospective case series. When performing aspiration, ensure that the Indigo Aspiration Tubing valve is open for only the minimum time needed to remove thrombus. The low-profile catheter and Penumbra . This press release features multimedia. These pages are not intended for patients or for members of the general public. Do not use petroleum based compounds, acids, caustics, or chlorinated solvents to clean or lubricate any parts. Applicant. The Indigo SystemCAT3, CAT5, CAT6, CAT8 and CATD are engineered to be robust, durable, and trackable for use in the peripheral anatomy. 1. Brian Kolski, MD The Penumbra ENGINE is intended as a vacuum source for Penumbra Aspiration Systems. This is potentially more effective than diminished syringe-based aspiration. Potential Adverse Events Maintain a constant infusion of appropriate flush solution. Created with Sketch. Contraindications The INDIGO Aspiration System is intended to serve as a conduit to assist in thrombus removal and restoration of blood flow in the peripheral vasculature and for the treatment of pulmonary embolism. Figure 1. Giri J, Sista AK, Weinberg J, et al. Kingsport, Tennessee The PENUMBRA ENGINE is intended as a vacuum source for Penumbra Aspiration Systems. Not for use in the coronaries or the neurovasculature. INDIGO Aspiration Tubing: As part of the INDIGO Aspiration System, the INDIGO Sterile Aspiration Tubing is indicated to connect the INDIGO CAT RX Aspiration Catheters to the Penumbra Aspiration Pump. Prior to the procedure, ticagrelor was administered and the patient was taken to the cardiac cath lab for angiography. Do not resterilize or reuse. Use prior to the Use By date. Please email info@medicalmaterials.com or call us at 877-663-8686 and we will try to locate the product with our suppliers. These pages are not intended for patients or for members of the general public. Do not use in the presence of a flammable anesthetic mixture with air or nitrous oxide. INDIGO SEPARATOR 4 is intended to be used with INDIGO CAT RX Aspiration Catheter to clear the distal end of the catheter lumen should it be blocked with thrombus. If the cause cannot be determined, withdraw the device or system as a unit. When performing aspiration, ensure that the INDIGO Aspiration Tubing is open for only the minimum time needed to remove thrombus. 2: Add window.dataLayer = window.dataLayer || []; Penumbra Aspiration Pump: The Penumbra Aspiration Pump is indicated as a vacuum source for Penumbra Aspiration Systems. Unrestrained torquing or forced insertion of the catheter or SEPARATOR against resistance may result in damage to the device or vessel. It will reduce service life of the Penumbra ENGINE. Medical Director, Aortic Disease and Ischemic Limb Disease The Indigo System CAT3, CAT5, CAT6, CAT8, CATD, and CAT7D are engineered to be robust, trackable, atraumatic, and well suited for the peripheral anatomy. Download scientific diagram | A, Penumbra Indigo System Continuous Aspiration Mechanical Thrombectomy Catheter (CAT8). gtag('js', new Date()); Do not resterilize or reuse. Return all damaged devices and packaging to the manufacturer/distributor. Penumbra, a US-based provider of advanced therapies, has enrolled the first patient into the CHEETAH clinical study, designed to evaluate the safety and performance of the Indigo System with CAT RX Aspiration Catheter in the coronary vessels. Excessive aspiration or failure to close the INDIGO Aspiration Tubing when aspiration is complete is not recommended. As part of the Indigo Aspiration System, the Indigo CAT RX Aspiration Catheters and Indigo Separator 4 (Penumbra, Inc.) are indicated for the removal of fresh soft emboli and thrombi from vessels in the coronary and peripheral vasculature. Due to continual vomiting, an electrocardiogram was obtained that showed an acute MI. Preprocedure TIMI 0 flow was seen in 76.3% of patients; TIMI 3 flow immediately post-CAT RX was demonstrated in 93.2% of patients. Figure 3. The Indigo System CAT RX with Penumbra ENGINE is an invaluable tool that is easy to set up and can provide rapid thrombectomy and immediate reperfusion. Her heart rate was 110 beats per minute, elevated troponin levels at 4.5 ng/mL, and elevated brain natriuretic peptide at 1,164 pg/mL. The patient had reported intermittent chest discomfort for 3 days, with some improvement with his daily medications. Mechanical clot engagement with proprietary Separator technology, Tip directionality for circumferential aspiration, The Indigo System is an integrated system for use only with other components of the Indigo System including the CAT family of catheters, Separators, Dynamic Aspiration Tubing, Lightning, Penumbra ENGINE, and Penumbra ENGINE Canister, Lightning Computer-Aided Aspiration comes packaged with CAT7 or CAT12, Live feedback during the procedure with integrated clot catcher, Penumbra ENGINE is capable of delivering and maintaining nearly pure vacuum (-29 inHg or 98.2 kPa) with the disposable Penumbra ENGINE Canister. In some cases, we have also seen a reduction in glycoprotein IIb/IIIa inhibitor usage (which may be associated with higher rates of bleeding). gus.theodos@bjc.org; @gtheodosmd Penumbra ENGINE Indication For Use Equipment is not safe for MR use. Angiograms showed pre- and postthrombectomy of the right pulmonary artery with modest clot debulking but significant improvement in right lung perfusion. Aspiration or disruption of thrombus with traditional diminished syringe-based aspiration or other mechanical devices is difficult, often incomplete, and has been associated with high complication rates.1 Use of medical therapy, such as powerful anticoagulants and thrombolytics (ie, tissue plasminogen activator), may carry a high risk of bleeding.2 The Indigo System was designed to provide sustained aspiration with Penumbra ENGINE to effectively remove thrombus, while reducing the risk of bleeding complications.3 The Indigo System utilizes atraumatic catheters varying in diameters from 3.4 to 8 F and lengths ranging from 50 to 150 cm. She had acute tubular necrosis with minimal urine output at the time of transfer. Pela bainha, foi introduzido o dispositivo de aspirao Penumbra Indigo System CAT8 XTORQ (Penumbra Inc., Alameda, Califrnia, Estados Unidos) em trombo segmentar, lobar ou arterial pulmonar principal, sendo realizada aspirao contnua (Figuras 2 e 3). Indigo Aspiration Catheters (CAT) are the foundation of Penumbras IndigoSystem. The final angiographic outcome revealed complete revascularization and TIMI 3 flow (Figure 2). The sustained aspiration power provided by the Penumbra ENGINE allowed rapid TIMI 3 flow restoration and removal of the distal emboli. After one pass with mechanical thrombectomy using CAT RX, the thrombus was removed and flow was restored to the pedal arch via the plantar posterior tibial artery (Figure 2 and Figure 3). Final angiography was performed, showing complete resolution of the underlying lesion (Figure 2). QUICK VIEW. If such use is necessary, LIGHTNING Aspiration Tubing and the other equipment should be observed to verify that they are functioning properly. INDIGO Aspiration Tubing: Figure 2. Use the INDIGO Aspiration System in conjunction with fluoroscopic visualization. CAT RX is an essential tool in our percutaneous coronary armamentarium. A CAT8 Penumbra catheter was advanced over the Glidewire into the right superficial femoral artery. Warnings/Precautions The procedure time was short (median of 37 minutes)the shortest demonstrated so far in an investigational device exemption (IDE) trial on patients with pulmonary embolism. Disclaimer: The opinions and clinical experiences presented herein are for informational purposes only. Figure 2. Indigo Aspiration Catheters (CAT) are the foundation of Penumbra's Indigo System.The Indigo System CAT3, CAT5, CAT6, CAT8 and CATD are engineered to be robust, durable, and trackable for use in the peripheral anatomy. Disclosures: Consultant to Penumbra, Inc. A 65-year-old man presented emergently with an inferior wall MI. The Indigo System utilizes the Penumbra ENGINEaspiration source capable of delivering nearly pure, continuous vacuum to our catheters to remove thrombus in vessels of various sizes. As part of the Indigo Aspiration System, the Indigo CAT RX Aspiration Catheters and Indigo Separator 4 are indicated for the removal of fresh, soft emboli and thrombi from vessels in the coronary and peripheral vasculature. Catheters; CAT8 KIT Indigo System Aspiration Catheter 8 and Aspiration Tubing - XTORQ - 8Fr x 115cm . Bradenton Cardiology Center/Manatee Memorial Hospital The INDIGO SEPARATOR is not intended for use as a guidewire. Do not re-infuse blood or fluid from the canister back into the patient. In 2014, Penumbra broke into the peripheral thrombectomy space with the release of the first Indigo System catheters, the 5-F CAT5 catheter and the 3-F CAT3 catheter (Penumbra, Inc.). Tip directionality for circumferential aspiration, Live feedback during procedure with integrated clot catcher, Penumbra ENGINE is capable of delivering and maintaining nearly pure vacuum (-29 inHg or 98.2 kPa) with the disposablePenumbra ENGINE Canister. A minimally-invasive device, Indigo enables the restoration of blood flow in such cases as acute limb ischemia and venous thrombus. gtag('js', new Date()); Initial angiogram of the right pulmonary artery showing pulmonary embolism. The Indigo SystemCAT3, CAT5, CAT6, CAT8, CATD, and CAT RX are engineered to be robust, trackable, atraumatic, and well suited for the peripheral anatomy. Portable RF communications equipment (including peripherals such as antenna cables and external antennas) should be used no closer than 12 inches (30 cm) to any part of the PENUMBRA ENGINE. Penumbra System ACE 68 KIT Reperfusion Catheter & Penumbra Hi-Flow Aspiration Tubing - 6Fr x .068" x 132cm: 6Fr x .068" x 132cm $600.00. The patient received a 3.5- X 38-mm everolimus-eluting stent (Synergy drug-eluting stent [DES], Boston Scientific Corporation) with postdilation optimized by intravascular ultrasound (IVUS) and was then sent to the step-down unit. gtag('config', 'UA-18982160-1'); Penumbra Inc .cls-1{fill:#a6a699;}.cls-2{fill:#b5121b;}.cls-3{isolation:isolate;fill:url(#linear-gradient);}. The Indigo system CAT3, CAT5, CAT6, CAT8 and CATD are engineered to be robust, trackable, atraumatic and well suited for the peripheral anatomy. Penumbra's LANTERN Delivery Microcatheter integrates a highly trackable 2.6 F microcatheter with a high-flow lumen to facilitate confident delivery of Ruby Coil, POD, and Packing Coil even in tortuous anatomy. Figure 2. 5, 19. The pain became more intense and constant, so he presented to the ED. A woman in her 40s presented to the emergency department (ED) with acute onset chest pain of 4 hours duration. The Indigo System aspiration catheters are available in a range of lengths and diameters that, when connected to the Penumbra ENGINE pump, can atraumatically remove the thrombus present in various peripheral vascular beds. waqas.qureshi@umassmemorial.org Director of Cardiac & Peripheral Cath Lab For more information on the personal data that is collected by this website, please refer to Penumbras Privacy Notice. Complications from the use of this device in this manner could lead to death, permanent impairment, and/or the need for emergency medical intervention. Potential Adverse Events Do not resterilize or reuse. CHEETAH will focus on patients presenting with high-grade thrombus burden who receive frontline treatment with CAT RX. This website is intended for US audience only. Unrestrained torquing or forced insertion of the catheter or SEPARATOR against resistance may result in damage to the device or vessel. INDIGO Aspiration Catheters and Separators: As part of the INDIGO Aspiration System, the INDIGO Aspiration Catheters and Separators are indicated for the removal of fresh, soft emboli and thrombi from vessels of the peripheral arterial and venous systems, and for the treatment of pulmonary embolism. Placing guidewire too distal in the pulmonary vasculature or excessive manipulation of aspiration/guiding catheter in the smaller, peripheral, and segmental pulmonary artery branches can result in vessel perforation. Thrombus aspiration in patients with high thrombus burden in the TOTAL trial. 1. She had normal left ventricular systolic function with severe right ventricular dysfunction on her echocardiogram. Use the INDIGO Aspiration System in conjunction with fluoroscopic visualization. 2018;72:1589-1596. Learn more about Lightning. Unrestrained torquing or forced insertion of the catheter or SEPARATOR against resistance may result in damage to the device or vessel. The newest indication for the Indigo System is the treatment of pulmonary embolism; this indication comes on the heels of the promising results of the EXTRACT-PE trial. Use prior to the Use By date. The Indigo System is intended for the removal of fresh, soft emboli and thrombi from vessels of the peripheral and venous systems, and certain central circulatory systems conditions such as pulmonary emboli, using continuous aspiration.